Addiction to cortisone was the subject of the 1956 motion picture, Bigger Than Life , produced by and starring James Mason . Though it was a box-office flop upon its initial release,  many modern critics hail it as a masterpiece and brilliant indictment of contemporary attitudes towards mental illness and addiction.  In 1963, Jean-Luc Godard named it one of the ten best American sound films ever made.  John F. Kennedy needed to regularly use corticosteroids such as cortisone as a treatment for Addison's disease . 
Radiculopathy occurs when something irritates a spinal nerve—say a “slipped disc” causing a pinched nerve. This is also called sciatica . There are resident stem and other cells in the local tissues everywhere in our body. Many live around blood vessels. These are obviously also present in the disc and nerves in the epidural space and they usually play an important role in suppressing inflammation and repairing damage. We know, based on a copious in vitro (lab) data, that the high-dose steroids used in epidural injections can kill these cells. So the progression of the series of epidural steroid injections looks a little something like this:
With the numerous points we have to choose from for our steroid injections most will find the glutes and lateral (side) deltoid head to be the most comfortable and convenient points of administration. Injection sites such as calves and traps are highly warned against; although in terms of adequate injection sites they are fine, they can produce a fair amount of pain in the individual. No matter where you choose to inject always practice sanitary methods; do not reuse needles or syringes, clean the area thoroughly before injection and always sterilize with alcohol beforehand.