New steroid for the brain

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We identified 20 trials with 12,303 randomised participants. The effect of corticosteroids on the risk of death was reported in 17 included trials. Due to significant heterogeneity we did not calculate a pooled estimate of the risk of death. The largest trial , with about 80% of all randomised participants, found a significant increase in the risk ratio of death with steroids (95% CI to ) and a relative risk of death or severe disability of (95% CI to ). For infections the pooled risk ratio from five trials was (95% CI to ) and for the ten trials reporting gastrointestinal bleeding (95% CI to ).

இறப்பு மற்றும் இயலாமைக்கு புறவழி மூளைக் காயம் ஒரு முக்கிய காரணம். மூளை காயம் ஏற்பட்டவுடன் அது மூளை வீக்கத்தை ஏற்படுத்தி, உயிருக்கே ஆபத்தை உண்டாக்கும் உள்மண்டை அழுத்தத்தை அதிகரிக்கும். கார்டிகோஸ்டெராய்டு மருந்துகள் பரவலாக உள்மண்டை அழுத்தத்தை குறைக்கும் என்று எண்ணி மூளை காயம் ஏற்பட்ட நோயாளிகளுக்கு, பல ஆண்டுகளாக, பயன்படுத்தப்பட்டு வருகின்றன. டெக்ஸாமீதாசோன் மற்றும் மெத்தில்ப்ரிடினிசோலன் போன்றவை கார்டிகோஸ்டீராய்டுகளின் சில உதாரணங்கள்.

Depending on the number and character of their functional groups, steroid molecules may show diverse reactivities. Moreover, the reactivity of a functional group varies according to its location within the molecule (for example, esters are formed readily by 3-OH groups but only with difficulty by the 11β-OH group). An important property of steroids is polarity —., their solubility in oxygen-containing solvents (., water and alcohols ) rather than hydrocarbon solvents (., hexane and benzene ). Hydroxyl, ketonic, or ionizable (capable of dissociating to form electrically charged particles) groups in a steroid molecule increase its polarity to an extent that is strongly influenced by the spatial arrangement of the atoms within the molecule.

New steroid for the brain

new steroid for the brain

Depending on the number and character of their functional groups, steroid molecules may show diverse reactivities. Moreover, the reactivity of a functional group varies according to its location within the molecule (for example, esters are formed readily by 3-OH groups but only with difficulty by the 11β-OH group). An important property of steroids is polarity —., their solubility in oxygen-containing solvents (., water and alcohols ) rather than hydrocarbon solvents (., hexane and benzene ). Hydroxyl, ketonic, or ionizable (capable of dissociating to form electrically charged particles) groups in a steroid molecule increase its polarity to an extent that is strongly influenced by the spatial arrangement of the atoms within the molecule.

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