Corticosteroiden werking

Fludrocortisone, also known as 9α-fluorocortisol (9α-fluorohydrocortisone) or as 9α-fluoro-11β,17α,21-trihydroxypregn-4-ene-3,20-dione, is a synthetic pregnane steroid and a halogenated derivative of cortisol (11β,17α,21-trihydroxypregn-4-ene-3,20-dione). [1] [2] Specifically, it is a modification of cortisol with a fluorine atom substituted in place of one hydrogen atom at the C9α position. [1] [2] Fluorine is a good bioisostere for hydrogen because it is similar in size, with the major difference being in its electronegativity . The acetate form of fludrocortisone, fludrocortisone acetate, is the C21 acetate ester of fludrocortisone, [1] [2] and is hydrolyzed into fludrocortisone in the body. [14]

Corticosteroiden werking

corticosteroiden werking

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