Bioconversion of steroids

Addiction to cortisone was the subject of the 1956 motion picture, Bigger Than Life , produced by and starring James Mason . Though it was a box-office flop upon its initial release, [15] many modern critics hail it as a masterpiece and brilliant indictment of contemporary attitudes towards mental illness and addiction. [16] In 1963, Jean-Luc Godard named it one of the ten best American sound films ever made. [17] John F. Kennedy needed to regularly use corticosteroids such as cortisone as a treatment for Addison's disease . [18]

Quality of Individual Studies and Determination of Evidence Strength. The systematic review included 303 eligible studies that addressed the pre-identified questions of interest. A large body of evidence evaluated established chemotherapy agents such as docetaxel [19 Randomized controlled trials (RCTs)], estramustine (5 RCTs) and mitoxantrone (5 RCTs). Randomized evidence was also available for various immunotherapies (8 RCTs), therapies targeting the androgen signaling pathway (12 RCTs), radiotherapy and radiopharmaceuticals (4 RCTs) and bone-targeting therapies (6 RCTs). The quality of these trials was acceptable overall and ranged from moderate to low risk of bias. All the remaining studies were otherwise non-randomized (observational) and considered to be at high risk of bias.

A research work on 5a Hydroxy laxogenin and 5α -Hydroxy laxogenin on athletic performance was conducted and showed below, at the intensive training period during the double-blind study of one hundred volunteered healthy male body builder for 4weeks. The volunteer for the test was divided into three different groups and was assigned to receive 5α-Hydroxy laxogenin, laxogenin and placebo (isomaitulose) on a daily basis respectively. The scheduled routine training for the subject includes barbell bench press; barbell bicep curls, and seated leg press at 65% maximum exercise, the upper arm circumference, bust, and thigh circumference on a weekly basis .The case study were not allowed to take a new supplement or drug, and their daily food were not changed suddenly while maintaining the intake of protein at a constant rate. The result from the research shows that placebo,  5a Hydroxy laxogenin administration had a significant effect on increase strength and endurance, broad arms, legs and shoulders. In conclusion it’s known that  5a Hydroxy laxogenin can enhance to have a stronger and healthier body.

Intraocular pressure, glaucoma
Have you heard of DHEA causing high IOP (intraocular pressure) or possibly temporary glaucoma. I have been taking DHEA for about a year. I like the benefits it has provided both physically and mentally. However my last flight physical for the military showed me having high IOP in both eyes. Two days after I stopped taking DHEA my pressures where back to normal.
   I have not heard of this side effect yet, and I have not seen it mentioned in the medical literature, however it is a possibility to consider. There's a lot we don't know about the long term effects of DHEA. If your IOP is increased again after restarting the DHEA and then returns to normal after stopping, then that would make it quite likely that in your case it was involved.

The bulk of published literature indicates that the expression of 5 α -R1 increases and 5 α -R2 decreases in CaP compared to benign prostate and BPH. Umera et al. confirmed for the first time increased expression of 5 α -R3 at the mRNA level in CR-CaP. Godoy et al., confirmed this at the protein level. A validated monoclonal antibody showed that expression of 5 α -R3 was increased similarly in AS-CaP and CR-CaP compared to AS-BP. 5 α -R3 expression was increased in lung, breast, papillary thyroid, and testicular (seminoma and yolk sac) cancers compared to their benign counterparts.

Bioconversion of steroids

bioconversion of steroids

Intraocular pressure, glaucoma
Have you heard of DHEA causing high IOP (intraocular pressure) or possibly temporary glaucoma. I have been taking DHEA for about a year. I like the benefits it has provided both physically and mentally. However my last flight physical for the military showed me having high IOP in both eyes. Two days after I stopped taking DHEA my pressures where back to normal.
   I have not heard of this side effect yet, and I have not seen it mentioned in the medical literature, however it is a possibility to consider. There's a lot we don't know about the long term effects of DHEA. If your IOP is increased again after restarting the DHEA and then returns to normal after stopping, then that would make it quite likely that in your case it was involved.

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